Wednesday, 23 September 2009

BNF advice on drug doses adjustments in CKD

The British National Formulary has revised its guidance on drug dose adjustments in Chronic Kidney Disease. For most drugs, for most patients over 18 years of age of average build and height, the eGFR (derived from the modification of diet in renal disease formula) can be used to determine dosage adjustments in place of creatinine clearance. Exceptions include potentially toxic drugs with a small safety margin, and patients at both extremes of weight. The BNF have replaced its references to creatinine clearance with eGFR where applicable and revamped its Appendix 3 to include a table grading renal function according to eGFR. Why don’t you try your hand at the case study?